18 months Postdoctoral Researcher – Protein stability prediction by screening and data modelling

Position overview

Join our innovative team to drive the development of cutting-edge therapeutic solutions. In this pivotal role, you’ll collaborate closely with experts to push the boundaries of scientific discovery, ultimately accelerating the delivery of life-changing treatments to patients in need.

Company introduction

Symphogen, the Antibody Center of Excellence within the Servier Group, is dedicated to developing antibody-based therapeutic products for treating cancer and neuroinflammatory diseases. Our Analytical Development team plays a crucial role in advancing our targets through lead selection, clinical development, and commercialization. Our state-of-the-art laboratory is equipped to handle all aspects of protein testing, and the analytical development department comprises 20 scientists and technicians specializing in protein analysis to support characterization, method development, troubleshooting, process development, validation, stability studies, and more.

Objective

This position focuses on the development of innovative tools to accelerate the development of Symphogen’s biologic molecules. We are seeking a highly motivated Postdoctoral Researcher to join our team for an 18-month project, with the possibility of an 18-month renewal.
Our goal is to broaden, automate and speed up our development workflows to bring our biologic candidates to patients as early as possible.
The project aims at predicting the long-term stability of mAbs and related formats. This project plays a fundamental role in advancing our efforts to develop stable, effective protein-based therapeutics for the patient. The candidate will work at the interface between research and CMC, contributing to high-impact research with potential real-world applications.

As a post-doctoral researcher in the characterization team, you will strengthen our analytical capabilities in the service of the development of Symphogen’s drug products. During your project, your missions will be:

• to identify, challenge and implement screening methodologies (conformational and colloidal stability) with a focus on process automatization,
• to prepare and perform long-term stability study for different candidates and formulations
• to compile data to perform the data modeling of the long-term stability studies,
• to correlate stability data with the screening parameters to facilitate decision-making in our future drug development processes.

The ideal candidate for this position has:

• 2-3 years of experience in protein chemistry
• A Ph.D. degree within protein chemistry, analysis or similar.
• Excellent collaborative skills to be part of interdisciplinary teams, including the research team, drug substance team, and drug product development team. Experience and is a proficient communicator of results through reports, presentations, and publications.
• Fluency in English both written and spoken

As a person, curiosity, pragmatism, and proactivity are mandatory qualities. We are looking for someone highly motivated and willing to contribute to the innovation at Symphogen. A commitment to your work will be crucial for the success of this project as is your willingness to continuously improve your hard and soft skills. We don’t expect to find a candidate fulfilling all the criteria, but we expect that you will show great abilities to demonstrate why your application is relevant.

Resources, and Career Development

At Symphogen, the innovation is driven by state-of-the-art infrastructure, collaborative environment and management support. Our laboratory is furnished with essential analytical instrumentation allowing assessment of both colloidal and conformational stability (DLS, SLS, plate reader, Nanotemper Panta, FlowCam, HPLC, etc). You will have the opportunity to work alongside a team of experienced scientists and industry experts, fostering a collaborative atmosphere that encourages knowledge-sharing and innovation. This environment is not only conducive to producing impactful research but also to advancing your professional development.
The skills and experience gained will position you competitively for future roles within the pharmaceutical industry. We are committed to nurturing talent and providing avenues for growth, making this position an excellent steppingstone in your career.

Working at Symphogen

Symphogen offers a challenging job in a creative, goal-oriented, and value-based environment with a meaningful mission: to advance superior next-generation antibody therapeutics to improve patients’ lives. You will be part of a highly engaged and inspiring organization that values diversity, teamwork, and commitment. We offer good development opportunities and a relevant benefits package.

Duration: This is a 1½-year temporary position with the possibility of an additional 1½-year extension. Expected start date as soon as possible.

Traveling: Limited, up to ten days per year.

For further information about the position, please contact Scientist Alexandre Nicolas at +45 88 38 23 65 (anic@symphogen.com) or Team Manager Christian Glue at +45 88 38 24 09 (cglu@symphogen.com), or HR-Manager at +45 4526 5050.

If you are interested in applying for the position, please mark your application and CV with “Postdoc, Protein stability prediction” and send it to job@symphogen.com no later than December 20^th, 2024. Potential candidates will be invited for interviews as they apply, and we reserve the right to close the posting before the deadline.

About Symphogen: Symphogen A/S, a Servier company, is the Antibody Center of Excellence operating within research, early clinical stages, and CMC biologics development. We support Servier’s commitment to improving patients’ health and the R&D strategy within oncology, immune-oncology, and immunoinflammatory diseases. Our strategic focus is to apply a streamlined and effective antibody platform to discover and develop novel and innovative antibody therapeutics. Symphogen aims to continuously build antibody technologies and provide new discoveries and early development therapeutic antibody compounds as combination or stand-alone therapies.

Symphogen is located in Denmark, in the greater Copenhagen area (Ballerup), and currently employs approximately 150 people. Learn more at https://www.symphogen.com/